A Woman with a Mission: Dr. Zilola Khadjieva

Jun 22, 2026

The term “power woman” could have been created for someone like Dr. Zilola Khadjieva. At 34, she is a mother of four, a full-time physician, and a PhD researcher in Tashkent, Uzbekistan, dedicated to improving the lives of children with gastrointestinal diseases. She is a woman who continues to learn and lead while caring for her family and her little patients who depend on her expertise. Dr. Khadjieva’s passion has brought her to the OMI in Salzburg, and she recently played a key role in organizing an OMI satellite symposium in Tashkent. With the support of the OMI and the Children’s Hospital of Philadelphia, Dr. Khadjieva continued her professional journey through a one-month placement at the Division of Gastroenterology, Hepatology, and Nutrition. In June, she returned home with new knowledge and motivation to help advance pediatric gastroenterology in Uzbekistan.

“I had the opportunity to learn a great deal from the team. One of my patients, three weeks ago, was a 10-year-old child with severe ulcerative colitis. Through the CHOP team’s guidance, I learned about biologic therapy and its role in treating severe disease. The patient’s parents were initially afraid to start infliximab, but after I explained its safety and benefits based on what I had learned, they agreed to the treatment. The patient was on hormone therapy and azathioprine. At first, there was no response to the treatment. After biologic therapy, the patient’s condition improved significantly after starting infliximab.

I also learned how to select appropriate therapeutic strategies and follow evidence-based treatment algorithms while managing a patient after liver transplantation. This experience strengthened my ability to approach complex and severe clinical cases. After I, as a GI, followed up, I learned that another patient with liver transplantation is now doing better.

Perhaps the most valuable lesson I learned was the importance of a multidisciplinary team. I saw how different specialists work closely together, support one another, and collaborate to provide the best possible care for their patients.

I am currently applying these recommendations and guideline-based approaches in the management of another patient with severe Crohn’s disease, following the principles and treatment strategies I learned from the CHOP team.”

Read more about her experience in the detailed report below:

Introduction

From May 4 to June 5, 2026, I completed a five-week observership at the Children’s Hospital of Philadelphia (CHOP), one of the world’s leading pediatric healthcare institutions and academic medical centers. The observership was conducted within the Division of Gastroenterology, Hepatology and Nutrition and provided comprehensive exposure to advanced pediatric gastroenterology, inflammatory bowel disease, hepatology, liver transplantation, nutrition, intestinal rehabilitation, motility disorders, and advanced endoscopic procedures.
The primary objectives of this observership were to expand my clinical knowledge, observe multidisciplinary patient management, learn modern evidence-based approaches to pediatric gastrointestinal diseases, gain exposure to innovative diagnostic and therapeutic procedures, and develop professional and academic collaborations with internationally recognized experts in pediatric gastroenterology.
This observership represented a unique opportunity to experience clinical excellence, cutting-edge research, multidisciplinary teamwork, and high-quality medical education within one of the most respected pediatric institutions worldwide.

Clinical Activities

My daily clinical activities typically began with inpatient ward rounds from 8:30 AM to 12:00 PM. During these rounds, I observed the management of hospitalized patients with complex gastrointestinal, hepatological, nutritional, and motility disorders. Discussions included diagnostic evaluations, interpretation of laboratory and imaging findings, multidisciplinary treatment planning, and long-term management strategies.
The inpatient service demonstrated exceptional coordination among physicians, fellows, nurses, dietitians, pharmacists, psychologists, social workers, and surgeons. The collaborative approach ensured comprehensive patient care and timely decision-making, particularly for medically complex children.
In the afternoons, from 2:00 PM to 5:00 PM, I attended outpatient clinics with various attending physicians within the Division of Gastroenterology. These clinics provided valuable exposure to a wide range of pediatric gastrointestinal disorders and allowed me to observe longitudinal patient care, family counseling, treatment monitoring, and multidisciplinary follow-up.

Weekly Rotations

Week 1: General Gastroenterology

During the first week, I rotated through the General Gastroenterology service. This rotation provided exposure to both common and complex pediatric gastrointestinal disorders, including:

• Functional gastrointestinal disorders
• Chronic abdominal pain
• Gastroesophageal reflux disease
• Eosinophilic gastrointestinal diseases
• Celiac disease
• Constipation
• Feeding disorders
• Nutritional deficiencies
• Complex diagnostic evaluations

The outpatient clinics highlighted the importance of evidence-based medicine, individualized treatment plans, and strong communication between healthcare providers and families.
I observed how clinical decisions were guided by current guidelines, multidisciplinary consultation, and patient-centered care principles.

Week 2: Inflammatory Bowel Disease (IBD)

The second week focused on the Inflammatory Bowel Disease Center, one of the most specialized pediatric IBD programs internationally.
During this rotation, I observed the comprehensive management of children with Crohn’s disease and ulcerative colitis. Particular attention was given to:

• Diagnostic work-up
• Endoscopic assessment
• Histological interpretation
• Biologic therapy selection
• Therapeutic drug monitoring
• Nutritional management
• Disease activity monitoring
• Long-term treatment strategies

I was especially impressed by the multidisciplinary model of care involving gastroenterologists, nurses, dietitians, psychologists, and social workers.
The team demonstrated a highly individualized treat-to-target approach aimed at achieving deep remission and improving long-term patient outcomes. Discussions of complex and severe IBD cases provided valuable insight into modern management strategies and decision-making processes.

Week 3: Hepatology and Liver Transplantation

The third week was dedicated to Pediatric Hepatology and Liver Transplantation.
This experience exposed me to children with:

• Acute liver failure
• Chronic liver disease
• Autoimmune liver disorders
• Metabolic liver diseases
• Cholestatic liver diseases
• Post-transplant complications
• Long-term transplant follow-up

One of the most educational aspects of this rotation was observing the highly structured multidisciplinary care provided to liver transplant recipients.
I learned how transplant hepatologists, transplant surgeons, pharmacists, dietitians, infectious disease specialists, nurses, and social workers collaborate to ensure optimal outcomes.
The organization of post-transplant care demonstrated the importance of coordinated follow-up, standardized protocols, and early identification of complications.

Week 4: Nutrition Team

During the fourth week, I joined the Pediatric Nutrition Service.
This rotation emphasized the critical role of nutrition in pediatric healthcare and provided valuable exposure to:

• Growth assessment
• Nutritional rehabilitation
• Enteral nutrition
• Parenteral nutrition
• Feeding difficulties
• Malnutrition
• Nutritional support in chronic gastrointestinal diseases

I observed how nutrition specialists work closely with gastroenterologists and other healthcare professionals to optimize growth and development in children with complex medical conditions.
The individualized nutritional care plans demonstrated the importance of integrating nutrition into all aspects of pediatric gastroenterology practice.

Week 5: Motility Disorders and Advanced Procedures

The final week focused on Pediatric Motility Disorders and Advanced Endoscopy.
I observed the evaluation and management of patients with:

• Severe constipation
• Intestinal dysmotility
• Feeding disorders
• Functional bowel disorders
• Complex motility conditions

The multidisciplinary motility team demonstrated a sophisticated approach to diagnosis and treatment, incorporating clinical assessment, motility testing, nutritional management, and behavioral interventions.
A particularly valuable aspect of this rotation was exposure to advanced endoscopic procedures.
During the observership, I attended endoscopy sessions twice weekly and observed both diagnostic and therapeutic interventions. Among the procedures observed were:

• Diagnostic upper endoscopy and colonoscopy
• Therapeutic endoscopic procedures
• Endoscopic ultrasound-guided anal botulinum toxin injection
• Pyloric botulinum toxin injection
• Advanced procedural techniques for gastrointestinal disorders

These experiences expanded my understanding of innovative minimally invasive therapeutic options available in specialized pediatric centers.

Intestinal Rehabilitation Program (IRP)

One of the most inspiring components of my observership was learning about the Intestinal Rehabilitation Program (IRP).
The program provides comprehensive multidisciplinary care for children with intestinal failure and complex surgical gastrointestinal disorders. I observed how pediatric gastroenterologists, surgeons, nutrition specialists, nurses, pharmacists, and rehabilitation professionals collaborate to optimize intestinal adaptation and improve long-term outcomes.
What impressed me most was the continuity of care provided after surgical interventions. Rather than concluding treatment after surgery, the gastrointestinal team remained actively involved in long-term rehabilitation, nutritional management, and patient follow-up.
This integrated model significantly improves quality of life, reduces complications, shortens recovery time, and enhances long-term patient outcomes.
The IRP represents an outstanding example of multidisciplinary patient-centered care and serves as a model that could be adapted in many healthcare systems worldwide.

Academic and Educational Activities

An important component of the observership was participation in CHOP’s extensive educational and academic program.
Throughout the five weeks, I attended numerous conferences and multidisciplinary meetings, including:

• Hepatology Clinical Conferences
• Divisional Meetings
• Pancreatic Disorders Program Conferences
• IBD Case Conferences
• Clinical Conferences
• Journal Clubs
• Pediatric Grand Rounds
• Nutrition Seminars
• CHOP – Hospital of the University of Pennsylvania Conferences
• HUP GI Grand Rounds
• Chief Rounds
• Motility Case Conferences
• Motility Clinical Conferences
• Pathology Conferences
• Radiology Conferences
• Quality Improvement Conferences

These educational activities demonstrated CHOP’s strong commitment to continuous professional development, evidence-based medicine, quality improvement, and academic excellence.
The multidisciplinary discussions encouraged critical thinking, collaborative problem-solving, and lifelong learning.

Learning Healthcare Organization and Team Management

Beyond clinical knowledge, one of the most valuable lessons from this observership was understanding how highly specialized healthcare teams are organized and managed.
I learned how complex inpatient services function efficiently through structured communication, multidisciplinary meetings, standardized care pathways, and collaborative decision-making.
Particularly impressive were the care models developed for:

• Liver transplantation
• Severe inflammatory bowel disease
• Intestinal rehabilitation
• Complex motility disorders

These programs demonstrated how coordinated teamwork improves patient outcomes while maintaining high standards of quality and safety.
The organizational structure of CHOP provides an excellent example of how specialized pediatric services can function effectively while delivering highly individualized patient care.

Research and Professional Development

The observership also provided valuable exposure to CHOP’s exceptional research environment.
I observed how research, clinical care, education, and quality improvement initiatives are integrated into everyday practice. The commitment to scientific excellence was evident in conference presentations, journal clubs, research discussions, and ongoing clinical studies.
The quality of research conducted at CHOP was truly inspiring. The institution promotes innovation, collaboration, and evidence generation aimed at improving pediatric healthcare worldwide.
This experience strengthened my motivation to further develop clinical research projects in Uzbekistan, particularly in the fields of pediatric inflammatory bowel disease, intestinal barrier function, nutrition, microbiome research, and intestinal rehabilitation.
I also gained valuable insights into how academic centers successfully combine patient care with research productivity and educational excellence.

Mentorship and Professional Interactions

A particularly meaningful aspect of my observership was the opportunity to interact with internationally recognized leaders in pediatric gastroenterology.
I am deeply grateful to Dr. Asim Maqbool, Dr. Andrew Grossman, Dr. Peter Mamula, Dr. Tamir Diamond, and many other faculty members who generously shared their expertise and discussed patient cases in detail.
Their willingness to teach, explain clinical reasoning, and share their experiences significantly enriched my learning experience.
I would especially like to acknowledge Dr. Peter Mamula, whose kindness, encouragement, and genuine interest in my professional development were truly inspiring. His discussions regarding clinical practice, academic growth, future opportunities, and career planning were highly motivating and left a lasting impression on me.

Challenges

The primary challenge during the observership was adapting to a new healthcare environment and communication style. As expected in a large tertiary referral center, fellows and attending physicians managed substantial clinical responsibilities, which occasionally limited opportunities for prolonged discussions.
Nevertheless, all team members were welcoming, supportive, and dedicated to education. These challenges further enhanced my adaptability and appreciation for efficient communication within busy clinical environments.

Conclusion

My five-week observership at the Children’s Hospital of Philadelphia was an extraordinary educational, academic, and professional experience.
The observership provided comprehensive exposure to advanced pediatric gastroenterology, inflammatory bowel disease, hepatology, liver transplantation, nutrition, intestinal rehabilitation, motility disorders, and advanced endoscopic procedures. Equally valuable was the opportunity to observe world-class multidisciplinary teamwork, healthcare organization, quality improvement initiatives, and cutting-edge research.
This experience broadened my clinical perspective, strengthened my academic aspirations, and reinforced my commitment to evidence-based and patient-centered pediatric care.
I return to Uzbekistan with new knowledge, valuable professional connections, fresh ideas for clinical practice and research, and renewed motivation to contribute to the advancement of pediatric gastroenterology, medical education, and scientific research in my institution and country.
Another valuable aspect of this observership was the opportunity to meet fellow international observers from different countries and medical specialties. It was inspiring to interact with highly motivated physicians who shared a common commitment to learning, professional growth, and improving patient care. The exchange of experiences, ideas, and perspectives enriched the observership experience and fostered meaningful professional connections that may lead to future collaborations.
I am sincerely grateful to the faculty, fellows, nurses, researchers, and staff of the Children’s Hospital of Philadelphia for their hospitality, mentorship, and dedication to excellence. This observership will have a lasting impact on my professional development and future career.
I am also sincerely grateful to the Open Medical Institute (OMI) for providing this exceptional opportunity and supporting international medical education, professional development, and global collaboration.